Shigella spp. and enterotoxigenic Escherichia coli (ETEC) are the two main causes of diarrhoea globally and account for ~1bn cases and 400-600,000 deaths per year (WHO). Non-typhoidal Salmonella (NTS) is an important and growing cause of diarrhoea in Africa, where 2.1–6.5 million cases of NTS disease occur annually (CDC). All three species are also significant causes of travellers’ diarrhoea. Prokarium is developing a combined bacterial diarrhoea vaccine in collaboration with Mexican biopharmaceutical company Probiomed.