In 2016 the WHO declared the Zika virus (ZIKV) to be a “Public Health Emergency of International Concern”. ZIKV has been linked to a broad set of complications in pregnancy, including miscarriage, stillbirth, premature birth and eye problems with nearly a third of scans showing abnormalities in babies in the womb, including growth restrictions and microcephaly, in women infected with ZIKV. Unlike most insect-vectored diseases, ZIKV can also persist in semen and has been shown to spread as a sexually transmitted disease. Prokarium is working with Public Health England to evaluate novel vaccine candidates and develop a new ZIKV STI model.